cortisol

“Baby, you have the dreamiest antibodies…”

Posted on by Caroline Sober

There’s likely a percentage of the readers of this blog who, if presented with a photo montage of George Clooney, Brad Pitt, Javier Bardem, Daniel Craig, Denzel Washington, Ryan Gosling and other celebrity heartthrobs, might have to take a moment (or several) just to sit back, breathe deeply and appreciate the view. And who could blame us? They’re manly men, all. Easy on the eyes, fairly dripping with testosterone, make our hearts go pitter-pat, maybe make our loins jump just a little with subconscious fantasies of beautiful Clooney babies. What? It’s only natural! It’s biology!

But a recent research effort, published in the February 21 edition of the journal Nature Communications, asserts that our twitterpation (or Brad Pitterpation, as it were) may not be so much for these guys’ handsome faces, strong jawlines, broad shoulders, six-pack abs, that spot in the crook of their neck that probably smells really good…

*sigh*
*batting eyelashes*

Sorry, got distracted there for a second. No, it might not be their looks that we’re really lusting after, but their…robust immune systems? Their drop-dead sexy antibodies? Continue reading ““Baby, you have the dreamiest antibodies…””

This is Your Hippocampus on Cortisol

Posted on by Kari Kenefick
A maze photo.
Whether navigating a maze or other obstacles, decreasing stress will help.

Research published by  Dr. Joyce Yau et al. in the Journal of Neuroscience earlier this year examined whether negative effects of cortisol on memory could be blocked using antagonists for brain receptors for cortisol.

The researchers noted that  local brain amplification of glucocorticoids (cortisol)  by 11beta-hydroxysteriod dehydrogenase type 1 (11beta-HSD1) is “pivotal” in age-related memory loss.

Cortisol acts by binding to cell receptors. In their research, Yau and colleagues found that when levels of cortisol are low, a particular cortisol receptor is bound. However, at higher concentrations, cortisol has a spillover effect and binds a second receptor. Binding to this second receptor activates cellular processes in the brain that cause memory impairment.

The  receptors studied were the high-affinity mineralocorticoid receptor (MR) and low-affinity glucocorticoid receptor (GR). As models for memory impairment, they used aged C57BL/6J mice as controls. Also studied were 11beta-HSD1-deficient mice (-/-), which ordinarily show no age-related memory deficits. Mouse memory was tested with a spatial memory task, a Y maze. Continue reading “This is Your Hippocampus on Cortisol”