atherosclerosis

suPAR: A New Approach to Treating Cardiovascular Disease

Posted on by Riley Bell

Cardiovascular disease (CVD), continues to be the leading cause of death in the United States and worldwide. Many patients with CVD have signs of chronic kidney disease (CKD), and those with CKD are often times disproportionately affected by CVD.

This interconnectedness was further explored in a recent study published in the Journal of Clinical Investigation that identified a new immune target, suPAR, as a protein that causes kidney disease and atherosclerosis, the most common form of CVD. Unlike traditional approaches to treating CVD such as controlling blood pressure and lowering cholesterol, this breakthrough research offers a new approach to treatment from an entirely different perspective.

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Go with Your Gut: Understanding How the Microbiome and Diet Influence Health

Posted on by Mariel Mohns
microbiome_mouse_model

Over the past decade, microbiome research has provided key insights into the relationship between our gut and our health. There are trillions of organisms in our gut, comprising the microbiome that complements our human biology, distinct from our genome. These gut microbes affect us in many ways, from affecting our mental health to our ability to fight cancer.

At the University of Wisconsin-Madison, Federico Rey and his research group are trying to understand how our diet might help or harm the important microbial communities in our gut. “If we can understand how microbes interact with diet, we can personalize nutrition to match diet with the composition of the gut microbiome and promote health,” Rey says.

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