Promega Included On 2022 Top Workplaces USA List

Posted on by Riley Bell
Top Workplaces 2022 Logo

Promega Corporation has been named among the best places to work in the USA with a 2022 Top Workplaces USA Award. The Top Workplaces USA list, announced on February 1, is a program run by research firm Energage to recognize high-performing companies based solely on employee engagement surveys. The surveys measure the level of connection, motivation, and commitment employees feel for their companies.

Energage believes that improving engagement can directly impact performance, innovation, retention, and talent attraction. The 2022 USA winner’s list is calculated by comparing the survey’s research-based statements to predict high performance against industry benchmarks.

I am able to perform science in an environment that makes me feel as though I’m growing as a researcher…

—Promega Employee Survey Response

A Culture of Work-Life Balance

Promega also earned a “culture badge” for Work-Life Balance. Employee feedback showed this factor to be the company’s strongest culture driver. Culture badges are earned for scores that are in the top 25% of organizations in the same benchmark. 

Promega Director of HR Organizational Development, Darbie Miller points out how much Promega employees value the flexibility to flourish both at work and at home. “It is meaningful to all of us that employees continue to experience a culture that prioritizes flexibility to balance work and personal life. We are honored to receive this recognition and also to understand how to continue to evolve the employee experience at Promega.”

My co-workers care, I do work that makes me feel empowered, and I have the flexibility to be a real person with a real life.

—Promega Employee Survey Response

#LifeAtPromega

Promega offers welcoming careers where employees can stay, contribute and grow. We challenge our employees to change the world, to have more fun, to bring their full selves to work— in short, to take on a career that means more. At Promega, our employees do just that. Here, employees play a role in solving the world’s most pressing problems, experience camaraderie, gain satisfaction and get reward. We challenge ourselves to improve our local communities, to create an open, inviting and inclusive culture, to foster a work environment where collaborative givers, continuous learners, and ambitious go-getters thrive.

Our employees make an award like this possible, and we are grateful for the talent they bring every day. With an eye toward the future, we will continue to build on a culture that values science, sustainable business, and human well-being. We believe that every one of our employees has the potential to make a meaningful difference. And they do.

“It [my job] allows me to contribute to the betterment of mankind, the advancement of science, and success of my friends.”

—Promega Employee Survey Response
Word cloud generated from Promega Employee responses to survey
The Top Workplaces survey asked employees what three words best describe Promega culture. This word cloud reflects the employee responses.

It [my role] allows me to be my natural, gifted, independent self while accomplishing the greater goals of the company and being part of something spectacular.

—Promega Employee Survey Response

Promega is a leader in providing innovative solutions and technical support to the life sciences industry. We are committed to science advancement for improving life in the global community. With branches in16 countries and over 50 global distributors serving over 100 countries

Our tools and technologies support a wide range of work. This includes cell biology, protein analysis, drug development, human identification, and molecular diagnostics. Promega products are used in labs for academic and government research, forensics, pharmaceuticals, clinical diagnostics, and agricultural and environmental testing.

Discover a career at Promega that will give you the opportunity you need to make a difference.

Are you a student who is exploring possible careers outside of academia? Industry has many opportunities for scientists. Read some of our careers blogs to learn more.

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High-Molecular Weight DNA for Long-Read Sequencing

Posted on by AnnaKay Kruger

Imagine that you’re putting together a large, complex jigsaw puzzle, comprising thousands of exceptionally small pieces. You lay them all out and attempt to make sense of them. It would be far easier to assemble this puzzle were the pieces larger, containing more of the image advertised on the box. The same can be said when sequencing a genome.

high-molecular weight DNA Depiction of a DNA helix

Traditional short-read or next-generation sequencing relies on DNA spliced into small fragments (≤300 base pairs) and then amplified. While useful for detecting small genetic variants like single-base changes to the DNA, this type of sequencing can fail to illuminate larger variations (typically over 50 base pairs) in the genome. Long-read sequencing, or third generation sequencing, allows more accurate genome assemblies, facilitating better detection of structural variants like copy number variations, duplications, translocations and inversions that are too large to identify with short-read sequencing. Long-read sequencing has the capability to fill in “dark regions” of a genome that are unfinished and can be used to assemble larger, more complex genomes using longer fragments of DNA, or high-molecular weight (HMW) DNA.

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Promega Ibérica Partnership Helps Students See Careers in Biotech

Posted on by Jordan Nutting

Graduate students often struggle to envision careers outside of the academic world. A partnership between Promega Ibérica and the Universidad Autónoma de Madrid (UAM) is helping change that for students in UAM’s Cellular Dynamics and Biomolecules master’s degree program.

María Jurado Pueyo, an application support manager with Promega Ibérica’s technical services department, leads a lab session on protein:protein interactions at the Universidad Autónoma de Madrid. As a part of the course students can explore careers in biotech.
María Jurado Pueyo, an application support manager with Promega Ibérica’s technical services department, leads a lab session on protein:protein interactions at the Universidad Autónoma de Madrid.
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Real-Time Analysis for Cell Viability, Cytotoxicity and Apoptosis: What Would You Do with More Data from One Sample?

Posted on by Kari Kenefick

Originally posted May 25, 2017. Updated 2022

You are studying the effects of a compound(s) on your cells. You want to know how the compound affects cell health over a period of hours, or even days. Real-time assays allow you to monitor cell viability, cytotoxicity and apoptosis continuously, to detect changes over time.

Why use a real-time assay?
A real-time assay enables you to repeatedly measure specific events or conditions over time from the same sample or plate well. Repeated measurement is possible because the cells are not harmed by real-time assay reagents. Real-time assays allow you to collect data without lysing the cells.

Advantages of  Real-Time Measurement
Real-time assays allow you to:

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COVID-19 Antiviral Therapies: What Are the New Drugs, and How Do They Work?

Posted on by Ken Doyle

We’re entering the third year of the global COVID-19 pandemic, and it’s far from over. There has been considerable progress with SARS-CoV-2 vaccine development, with most of the focus on mRNA vaccines and adenoviral vector vaccines. Meanwhile, novel vaccine delivery systems are being tested among efforts to develop a “pan-coronavirus” vaccine that is effective against multiple variants. One such example is ferritin nanoparticle technology developed by researchers at the Walter Reed Army Institute of Research and their collaborators. Encouraging results from nonhuman primate studies, using several SARS-CoV-2 antigens, were published in 2021 (1–3).

New COVID-19 antiviral therapies offer promise, but further data are needed before they become widely available.

The current surge in COVID-19 cases that began last month is largely due to the Omicron variant in the US, according to data from the US Centers for Disease Control and Prevention (CDC). At present, we still don’t know enough about this variant, but it’s clear that its rapid spread is forcing us to re-examine what we know about SARS-CoV-2 (4). As the virus continues to mutate, new variants will continue to emerge and spread. Although current vaccines can provide protection against multiple variants, breakthrough infections are a concern. Vaccination is still the best option to reduce the risk of infection, hospitalization, and death compared to unvaccinated people.

It’s clear that vaccines are only part of an effective response to fighting the pandemic. Along with continued vaccine development efforts, attention must also be given to antiviral drug development for people already infected with COVID-19. Due to the lengthy process for new drug development, early efforts focused on repurposing existing drugs.

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MISpheroID: A Knowledgebase to Improve Reproducibility in Spheroid Research

Posted on by Johanna Lee
Spheroid research is now a common component of cell biology and drug discovery science

Advantages of Spheroids

In the past decade, there has been a sharp rise in studies using spheroids as cell models for basic research and drug discovery. Spheroids are self-organized aggregation of cells that form a spherical mass, and they have become widely popular because they are much more physiologically relevant compared to flat 2D cell cultures.

In spheroids, the inner cells have less access to nutrients and oxygen compared to the outer layer, forming a natural gradient. As a result, metabolite concentration and cellular state such as proliferation and differentiation, can be very different at the periphery compared to the inner core. This phenomenon, known as “heterogeneity”, makes 3D tumor spheroids much more representative of actual tumors in the human body.

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Total Eclipse of the CAR T: How mRNA Vaccine Technology Can Be Used to Help Heal “Broken” Hearts

Posted on by Natalie Larsen

While you can rely on Taylor Swift and Adele to help heal emotional heartbreak, unfortunately treating a physically “broken” heart, a heart damaged by fibrosis, is a much more complicated process than putting on your favorite sad songs and wallowing in your feelings. In a recent study published in Science, researchers developed a therapeutic approach to treat damaged hearts in mice through the removal of scar tissue using genetically engineered immune cells (CAR T cells) and the mRNA technology used in the mRNA coronavirus vaccines.

Genetically engineered CAR T cells have been used l for repairing damaged hearts in mice
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Kicking Off the New Year with Three Popular Plant Papers

Posted on by Riley Bell

It’s officially 2022, Happy belated New Year! A lot of amazing research is trending in science news right now. In particular, take a look at three plant-related papers that discuss interesting research and advancements in plant science.

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Run to Remember: A Mouse-Model Study Investigating the Mechanism of Exercise-Induced Neuroprotection

Posted on by Michele Arduengo

Research in animal models shows physical exercise can induce changes in the brain. In humans, studies also revealed changes in brain physiology and function resulting from physical exercise, including increased hippocampal and cognitive performance (1). Several studies in mice and rats also demonstrated that exercise can improve learning and memory and decrease neuroinflammation in models of Alzheimer’s disease and other neurodegenerative pathologies (2); these benefits are tied to increased plasticity and decreased inflammation in the hippocampus in mice (2). If regular time pounding the pavement does improve brain function, what is the underlying molecular biology of exercise-induced neuroprotection? Can we identify the cellular pathways and components involved? Can we detect important components in blood plasma? And, is the benefit of these components transferrable between organisms? De Miguel and colleagues set out to answer these questions and describe their results in a recent study published in Nature.

A recent study investigates the underlying molecular mechanisms of exercise-induced neuroprotection in a mouse model.
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Making Sense of Climate Change

Posted on by Jordan Nutting

Earlier this year, I had an opportunity to attend a virtual talk presented by leading climate scientist and communicator Dr. Katharine Hayhoe. She began by asking the audience to send in one word that describes how they feel when thinking about climate change. The responses popped up live in a word cloud on Hayhoe’s shared screen:

Anxious

Frozen

ARGHH!

Those words also describe how I felt when I realized the conclusion to my series of blogs on the 2021 Nobel Prizes would address the topic of climate change.

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