Science Education

2023 Promega iGEM Grant Winners: Tackling Global Problems with Synthetic Biology Solutions

Posted on by Michele Arduengo

On June 15, 2023, we announced the winners of the 2023 Promega iGEM grant. Sixty-five teams submitted applications prior to the deadline with projects ranging from creating a biosensor to detect water pollution to solving limitations for CAR-T therapy in solid tumors. The teams are asking tough questions and providing thoughtful answers as they work to tackle global problems with synthetic biology solutions. Unfortunately, we could only award nine grants. Below are summaries of the problems this year’s Promega grant winners are addressing.

UCSC iGEM

An immature night heron against the green surface of Pinto Lake. 2023 Promega iGEM Grant Winner, UCSC iGEM seeks to mitigate these harmful aglal blooms.
A night heron hunts on Pinto Lake, California.

The UCSC iGEM team from the University of California–Santa Cruz is seeking a solution to mitigate the harmful algal blooms caused by Microcystis aeruginosa in Pinto Lake, which is located in the center of a disadvantaged community and is a water source for crop irrigation. By engineering an organism to produce microcystin degrading enzymes found in certain Sphingopyxis bacteria, the goal is to reduce microcystin toxin levels in the water. The project involves isolating the genes of interest, testing their efficacy in E. coli, evaluating enzyme production and product degradation, and ultimately transforming all three genes into a single organism. The approach of in-situ enzyme production offers a potential solution without introducing modified organisms into the environment, as the enzymes naturally degrade over time.

IISc-Bengaluru

Endometriosis is a condition that affects roughly 190 million (10%) women of reproductive age worldwide. Currently, there is no treatment for endometriosis except surgery and hormonal therapy, and both approaches have limitations. The IISc-Bengaluru team at the Indian Institute of Science, Bengaluru, India, received 2023 Promega iGEM grant support to investigate the inflammatory nature of endometriosis by targeting IL-8 (interleukin-8) a cytokine. Research by other groups has snow that targeting IL-8 can reduce endometriotic tissue. This team will be attempting to create an mRNA vaccine to introduce mRNA for antibody against IL-8 into affected tissue. The team is devising a new delivery mechanism using aptides to maximize the delivery of the vaccine to the affected tissues.

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From Biotechnology Youth Apprenticeship to Full-Time Promega Scientist

Posted on by Jordan Villanueva
Headshot photos of Emily Torio, Lucas Slivicke and Kirsten Wingate, three Promega scientists who participated in the Youth Apprenticeship Program.

The Biotechnology Youth Apprenticeship Program hosted by the BTC Institute gives high school students an opportunity to gain hands-on experience in a research lab. Students can work as paid apprentices for either one or two years while also attending weekly training sessions at the BioPharmaceutical Technology Center. Through this program, students can graduate high school with robust knowledge of lab safety and fundamental techniques, as well as a strong understanding of the soft skills required to succeed in science, from reading peer-reviewed literature to delivering a research presentation.

Many of these students will grow up to pursue careers in science, from academic research labs to the biotechnology industry. Some of them have returned to Fitchburg to work at Promega, the primary corporate sponsor of BTC Institute. As these scientists progress in their careers, the skills they developed in the Youth Apprenticeship Program continue to support their work every day.

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Left-Handed DNA: Is That Right?

Posted on by Ken Doyle

There’s a certain group of people (including this blog post author) who derive no small amount of amusement from seeing stock photos of DNA and pointing out flaws in the structure. It’s even more amusing when these photos are used in marketing by life science companies. The most common flaw: the DNA molecule is a left-handed double helix.

What does that even mean? DNA, like many organic chemicals in biology, is a chiral molecule. That is, it can exist in two structural forms that are mirror images of each other but are not superimposable (enantiomers). Just like your left and right hands are mirror images of each other, the two DNA structures are left-handed and right-handed double helices. The DNA double helix is chiral, because its building blocks (nucleotides) are chiral.

Two DNA helices that are mirror images

It can be challenging, at first glance, to tell whether an image of DNA is left-handed or right-handed. Various helpful hints are available; however, the one that I’ve found easiest to remember is described in a blog post by Professor Emeritus Larry Moran at the University of Toronto:

Imagine that the double helix is a spiral staircase, and you’re walking down the staircase. If you’re turning to the right as you descend, the DNA structure is right-handed; if turning to the left, it’s left-handed. In the image shown earlier, the DNA molecule on the right is a right-handed double helix, while its mirror image is left-handed.

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Onward with Online Learning!

Posted on by Riley Bell

National Online Learning Day is celebrated annually on September 15, and although it was only created in 2016, it’s a growing “day”. This day highlights students of all ages who have the ability to learn anywhere, anytime, and thrive wherever their technology and imagination take them.

Technology in the past decade has completely transformed and built bridges in education. Even before the pandemic, online learning was growing and being adopted. As we entered the COVID-19 pandemic, educational institutions were forced to think digitally, and our viewpoint of online education shifted from “option” to “necessity”.

Whether you’re enrolled in a virtual course, working from home, or sitting in on a virtual conference, nearly all of us, at some compacity, take part in online learning—and it’s here to stay! The ability to learn online will continue to provide people with new resources and support for many years to come. Let’s dive into some advantages of online learning and discover helpful resources to thrive online.

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The Bell Burnell Observatory: 140 Years of Inspiring Scientific Curiosity

Posted on by Jordan Villanueva
The Bell Burnell Observatory, located at Promega Madison

On a hill at the top of the Promega Madison campus, an old observatory overlooks the city of Fitchburg, Wisconsin. Inside, cutting-edge telescopes are ready to give students and astronomers breathtaking views of the cosmos.

Over the past 140 years, this observatory has served as the first launchpad for storied careers in astronomy. Following a relocation, it gave a passionate community a home for their curiosity. Today, it supports modern research while also welcoming stargazers of all ages. It is now one of the oldest operational observatories in the United States. This is the Bell Burnell Observatory.

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The BTC Institute: Serving Youth Skills and Science for Summer

Posted on by Riley Bell

World Youth Skills Day provides a unique opportunity to emphasize the importance of equipping young people with experiences, skills, and opportunities in the workforce. This celebratory day falls on July 15th and was officially declared by the United Nations General Assembly in 2014.

At Promega, we are constantly adhering to invest in the future generations of science—and the BioPharmaceutical Technology Center Institute (BTC Institute) serves this mission best. The BTC Institute is a non-profit organization that provides educational, scientific, and cultural opportunities for people of all ages. Each summer, the organization hosts a wide range of experiences including camps, programs, and field trips to support individuals interested in science. In the spirit of World Youth Skills Day, let’s take a look at some experiences that are offered for young learners in summer 2022.

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Promega Highlights Innovative Work with Brazil Young Researcher Award

Posted on by AnnaKay Kruger


In late May 2022, Promega invited the nine finalists for the Promega Brazil Young Researcher Award to present their work at a Student Research Symposium on the Promega Madison campus.

Scientists from around Brazil recently traveled to Madison, WI, USA as part of the Brazil Young Researcher Award

The Brazil Young Researcher Award program was created to acknowledge exceptional work by Brazilian students utilizing Promega products in their research. These student researchers were recognized for their achievements and were given the opportunity to present their innovative research to Promega scientists as part of a week-long immersive experience on the Promega campus.

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Squid Games: Camouflage or Communication, It’s All Skin Deep

Posted on by Nana Diarra dit Konté
One Out winning image of Promega AG Art + Science Competition shows baby squid communicating
One Out (winner Promega AG Swiss Art + Science Competition) by Urhs Albrecht, University of Fribourg

Squids are mysterious creatures roaming seas and oceans. They are also the subjects Urs Albrecht chose for his winning picture in the Swiss Art + Science competition, “One Out.” The photo shows squid juveniles, one of which displays striking colors in opposition to the rest. The bright individual is also physically removed from the group, may be scared or angry. The image is fascinating because we can see complex biology at play with the naked eye. Squids are Coleoid cephalopods, mollusks with arms attached to their heads. They have lost their shell and developed larger and highly differentiated brains and camera-type eyes through evolution. Their nervous system is highly organized. The central brain acts as the decision-making unit, and the peripheral nervous system processes motor and sensory information.

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Kornberg Innovation Seminars: Inspiring Creativity in Promega R&D

Posted on by Jordan Villanueva
Kornberg Center was designed to accelerate scientific exploration.

“Are you going to the talk?”

The refrain regularly echoes through the halls of every academic lab building. During our education, we’re treated to a non-stop supply of speakers on every subject we can imagine. Prestigious speaker series gave us chances to hear from some of the world’s most prominent experts on subjects that would shape scientific pursuits for the next decade and beyond. When we leave academia, however, it can be difficult to find those same opportunities to learn. Sure, there are lab meetings and conferences, but when can you be treated to a renowned expert giving a talk just down the hall?

Promega Head of Biology Frank Fan aimed to address that problem when he developed a plan for the Kornberg Innovation Seminars (KIS), a recurring speaker series to be held in the new home for Promega R&D. Kornberg Center is an environment where Promega scientists are challenged to think outside-the-box and anticipate the challenges life science researchers will be facing tomorrow. Frank believed that opportunities to learn from a wide variety of guest experts would be critical for inspiring that type of thinking.

“Promega R&D focuses on understanding scientists’ needs and providing novel solutions,” Frank says. “The KIS program is about helping us achieve that vision.”

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Empowered Women Empower Women: Closing the Confidence Gap in STEM

Posted on by Natalie Larsen

Welcome back to the third and final part of our Women in Science series, where we’ve been exploring the key factors that perpetuate the gender gap in STEM. In Part 1 of this series, Breaking the Bias: Addressing the STEM Gender Gap, we dug into the key factors of gender stereotypes and male-dominated culture. Part 2, This is What a Scientist Looks Like: The Importance of Female Role Models in STEM, was all about the issue of fewer visible female role models in STEM. Last but certainly not least, this installment will focus on tackling the issue of the confidence gap, including the factors that play into it and the myriad ways we see it unfolds.

Part of my exploration of this topic included having conversations with a handful of my incredible female colleagues at Promega about the challenges women in STEM face. These colleagues were (in no particular order): Becky Godat, Instrumentation Scientist; Jacqui Mendez-Johnson, Quality Assurance Scientist; Johanna Lee, Content Lead, Marketing Services; Jen Romanin, Sr. Director, IVD Operations and Global Support Services; Kris Pearson, Director, Manufacturing & Custom Operations; Leta Steffen, Supervisor, Scientific Applications; Monica Yue, Technical Services Scientist; and Poonam Gunjal, Manager, Regional Sales.

What is the Confidence Gap?

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