Ice Age Secrets: The Discovery of a Juvenile Sabretooth Cat Mummy 

In the permafrost of Siberia, a remarkable discovery has been made—a mummified juvenile sabretooth cat, Homotherium latidens, frozen in time for over 35,000 years. This discovery, made along the Badyarikha River in the Indigirka River Basin of Yakutia, Russia, offers an exciting glimpse into a species that has no modern analog (a living equivalent of something extinct) (1). For paleontologists and evolutionary biologists, it provides an unprecedented look at an ancient predator that roamed the Earth during the Ice Age. So, how is this cub mummy truly fascinating scientists?  

A Rare Find  

Homotherium Sabretooth mummy
The frozen mummy of Homotherium latidens: (A) external appearance; (B) skeleton, CT-scan, dorsal view (1).

The permafrost of Siberia is a treasure trove of Ice Age fossils, but the discovery of a mummified Homotherium cub stands out for its rarity and significance. While bones can tell us a lot about the history of an extinct species, mummies—where the animal’s soft tissues, such as fur, skin and sometimes internal organs, are preserved—offer far more detailed information. ‘Mummies’ refer to animals (or humans) that have been preserved with their soft tissues intact, often through natural or intentional processes like drying or embalming. This preservation allows scientists to gain insights into the organism’s diet, health, development and adaptations—details that bones alone can’t reveal! 

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Thanksgiving Cooking: Lessons in Chemistry

Thanksgiving dinner

With Thanksgiving just around the corner, kitchens across the country will soon be alive with the sights, smells and sounds of cooking. But what if we dove deeper into those recipe books and looked beyond the instructions? You might find you’re more than just a cook; you’re quite the chemist!  

Inspired by the popular show Lessons in Chemistry, an adaptation of Bonnie Garmus’s bestselling novel, cooking is presented as applied science, encouraging viewers to think critically about their cooking and the chemical reactions that create the flavors and textures they love. In this blog, we’ll explore the chemistry behind Thanksgiving cooking, revealing how different techniques bring out the best in each dish. 

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Extreme Makeover, Epidemic Edition: Can Ants Modify Their Nests for Survival?  

Ants on a hill

Imagine if your first instinct during an epidemic wasn’t to wear a mask or stock up on groceries, but instead to start rearranging and remodeling your house. As it turns out, researchers have found that black garden ants (Lasius niger) do exactly that when confronted with the threat of disease. These tiny architects instinctively spring into action, redesigning their nests in various ways to slow the spread of infection and protect their crowded colonies where diseases can easily spread.  

Read more about the research and see how these findings offer insights into how spatial changes – both in ants and potentially in human environments – can help limit the risks of infection.  

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Taking the Plunge: How the Seine Became Olympic-Ready

What would the Olympics be without a little controversy? From spy drones to air conditioning battles and debates over the bronze medal in women’s floor exercises, the 2024 Games had their fair share. Yet, amidst all the drama, one story stood out—the transformation of the Seine River. After being off-limits to swimmers since 1923, the Seine made a historic comeback this summer, hosting Olympic swimming events for the first time in modern history, including a 10K marathon, the aquatic portion of the triathlon and a Paralympic swimming event (4). With nearly 1 billion people watching, the Seine needed to be more than just swimmable – it had to be media-ready, as even a small misstep could have tarnished the river’s new image. 

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How Artificial Intelligence Revolutionized the 2024 Paris Olympics

At the end of July, many people across the globe were preparing to tune into the two-week, 2024 Olympic Games in Paris, France. The Olympics were slated to feature several high-profile athletes—including Simone Biles (USA, artistic gymnastics), Eluid Kipchoge (Kenya, marathon) and Marta Vieira da Silva (Brazil, football). However, in the lead-up to the Games, the International Olympic Committee (IOC) focused on a secondary player: Artificial Intelligence (AI). The IOC laid out an ambitious AI agenda aimed to enhance athlete performance, ensure fairness and optimize operations. The 2024 Paris Olympics represent a significant leap forward in integrating AI into the world of sports.

Together, we can unlock AI’s full potential to promote solidarity, further digitalization, improve sustainability and resilience, and reinforce the role of sport in society.” – Olympic AI Agenda

Here, we explore several applications of AI in the 2024 Paris Olympics.

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SLIM Chances: Upside-down, but not Out on the Lunar Surface

The lunar surface

The moon has perpetually been a beacon of curiosity to humankind, always in the sky urging us to look up and beyond. In the mid-20th century, this fascination sparked a historic rivalry between the United States and the Soviet Union, known as the Space Race. This era was marked by extraordinary milestones: satellites orbiting Earth, humans venturing into space and the landmark event of a man setting foot on the moon – a moment etched in history with the phrase, “One small step for (a) man, one giant leap for mankind.” It was an era where the impossible became possible – though some still question if it was a monumental human achievement or an elaborately crafted façade.

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Blending Art and Science in a Costa Rica Physics Lab

Sophia Speece engaged her passions for art and science during her internship in Costa Rica.
UW-Madison student Sophia Speece (left) spent the summer in Costa Rica for the “Artist in the Science Lab” internship hosted by alum Dr. Mariela Porras Chaverri (right)

My name is Sophia Speece. I am a junior at the University of Wisconsin-Madison studying Biomedical Engineering and Music Performance. As you can imagine, there is not a lot of overlap between these two passions of mine.

This past summer I was given the unique opportunity to combine these two areas. I applied and was accepted for the “Artist in the Science Lab” internship abroad in Costa Rica!

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More Than a Scientist: Paraj Mandrekar’s Career & Contributions to Tabletop Roleplaying Games

Paraj Mandrekar began his career at Promega in 1998 in the Genetic Identity Research and Development program. In 2001, he was a consultant at the World Trade Center to help meet the urgent need to identify victims of the 9/11 attacks. Two products, one of them being our DNA IQ™ System, that Paraj and others used for automating forensic DNA purification at the time were featured in the R&D 100 Award in 2002.

As he progressed through the successive ranks in R&D, Paraj took on more responsibility for the research, design, and development of novel chemistry. A significant high point in his career was being promoted to Senior R&D Scientist 1 in 2010. At that point, he was working on both forensic and non-forensic chemistries with paramagnetic particles. Promega’s non-forensic kit (AS1290) was launched with a new chemistry in March 2010, and a few months later, he got a new version of the Maxwell forensic sample kit (AS1240) out the door.

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Promega’s Top Three Most-Viewed Blog Posts of 2023

This year, our bloggers wrote about a range of topics, including semaglutide, a 20,000-year-old pendant, and type 1 diabetes. Each topic is unique and has proven its popularity by our Promega Connections readers! Take a look at our top three most-viewed blog posts of 2023. 

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Designing Science: A Behind-the-Scenes Look at Our Recent Journal Cover Art

A 3D illustration showing RAF inhibitor LXH254 engages BRAF or CRAF protomers (orange), but spares ARAF (red). Unoccupied ARAF is competent to trigger downstream mitogenic signaling, which is demonstrated with lightning bolts. Red cells in the background are fluorescently labeled RAS proteins, expressed in live cells. The Cell Chemical Biology cover type superimposes the image.
Image adapted from original artwork by iSO-FORM LLC.

We made the cover! Of Cell Chemical Biology, that is.

This July, Cell Chemical Biology editors accepted a study from Promega scientists and invited the research team to submit cover art for the issue. The study in question details a BRET-based method to quantify drug-target occupancy within RAF-KRAS complexes in live cells. Promega scientists Matt Robers and Jim Vasta collaborated with one of our talented designers, Michael Stormberg, to craft an image that accurately represents the science in a dynamic and engaging way.

You can check out the paper and cover art in the November 16 issue of Cell Chemical Biology.

I spoke with Michael Stormberg to learn more about the creative process that went into creating this cover art and how he worked with the research team and other collaborators.

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