Analogues

People who know me well have, at some point, heard me hold forth on the subject of Antarctica. It’s a passion of mine, though I’ve never been there. The forgotten continent is like the Sirens, pulling those who dare to trespass upon the ice back to one of the bleakest places on Earth.

I have consumed many accounts of life there, and have configured my internet services to deliver me news reports that deliver little crumbs of information. Anything that mentions Antarctica crosses my screen.

My fascination derives from boyhood dreams of space. Young visions of piloting starships and traversing Martian landscapes – visions of adventure, glory, and alien encounters – shattered in daylight on a January day in 1986 as I sat cross-legged on an elementary school gymnasium floor. It would be years before I saw 2001: A Space Odyssey, but watching the Challenger disintegrate into a fiery end, I immediately understood one of its central lessons: space is not glamorous, glorious, or any more alien than many of the places on our planet. Space is cold, unemotional, and unforgiving. It is intolerant of error, and it is lonely. And despite these things, it is where any future humans can hope to have must lie.

I will never go into orbit, but Antarctica, that’s the next best thing. Cold. Unforgiving. Intolerant of error. Nearly devoid of life except that which we import and resupply, it is where we troubleshoot the logistical problems of sustaining remote and isolated human colonies. Having spread across six other continents, it is our last terrestrial frontier.

No, I will never float among celestial bodies and listen to the low murmur of the universe rippling deep in the dark silence of space. But there is another place where we pursue science, a place closer to home, where I can be cold and alone and maybe catch a stray shard of a broken childhood dream.

Humorous New Types of PCR

Undoubtedly, the polymerase chain reaction (PCR) has revolutionized biological research and has become one of the most common techniques in today’s laboratory. At times, it seems that a new variation of PCR is described in the literature every month. You might think that you are familiar with the dozens of PCR variations, but I am guessing that you haven’t heard of some of these.

Continue reading “Humorous New Types of PCR”

Top Ten Uses for Pumpkin

In honor of Halloween, here is a Top Ten Uses of Pumpkin list for your enjoyment:

10. Means of transportation on the high seas or emergency flotation device (pumpkin boats; see the video).

9. Elementary Math Lessons. Determine circumference and radius. How much does a pumpkin weigh? Estimate the number of seeds. Check out pumpkin math ideas here.

8. Cholesterol-lowering snack. After ruthlessly scooping out the innards of a pumpkin, clean the seeds, bake them in the oven and enjoy your healthy snack. Pumpkin seeds contain phytosterols, compounds that that have been shown to reduce levels of LDL cholesterol, as well as magnesium, a mineral needed in the diet.

7. Physics Laboratory. Pumpkin Chuckin’ Contest (video).

Continue reading “Top Ten Uses for Pumpkin”

Following the Unexpected Path: Pipettes, Printers and Beyond

The unexpected path.....
The unexpected path.....

Someone once asked me how I decided to become an editor. My answer was: I didn’t. Sometimes careers just sort of evolve. I graduated from Iowa State University with a degree in genetics and moved to San Diego, the city of sun, sea air and biotech. My plan was simple; I was going to get a job doing lab work, and maybe someday I’d take a year off and write my book (Doesn’t everyone have a book they are going to write “someday”?). I loved research; I once wondered aloud how people who sat at desks all day could stay busy. What did they do all day? Were there really that many papers in the world that need shuffling about? In the lab I got to do something different every day: cloning, plasmid preps, cell culture, transfections, RNA preps, Northerns. It was like following a treasure map and not knowing what was under the big “X”. Continue reading “Following the Unexpected Path: Pipettes, Printers and Beyond”

Running A Victory Lap For Promega’s Bioluminescence Technologies

Helping scientists design experiments and interpret data is what we do best at Promega Technical Services. This may mean spending time at the bench attempting to reproduce anomalous results or forming a team, perhaps with members of other departments, to brainstorm seemingly intractable experimental road blocks.  Still, for many of us nothing surpasses the experience of meeting these same scientists face to face whether it be on their home turf or at a booth during a tradeshow. PCArticle Continue reading “Running A Victory Lap For Promega’s Bioluminescence Technologies”

Better Living through Design

ClearviewHwy in use on road signs in Madison, WI
ClearviewHwy in use on road signs in Madison, WI

Perhaps this is a sign that I need a more interesting life, but I was thrilled to see some of the highway signage in and around Madison, WI, start to change over to Clearview, a typeface designed specifically for road signs.

Nearly everyone who’s driven a car knows the limitations of the current standard for road signs, FHWA Series fonts (it is affectionately called “Highway Gothic” by typophiles). At night, the letters seem to blur together and glow, and some characters are difficult to distinguish from others.

Clearview is the result of nearly a decade of work, making a typeface that is more readable without increasing the dimensions of the existing road signs.

You can read about Clearview on the official website, and of particular interest is the Research section.

Describing Life and Death in the Cell

4621CALife is complicated. So is death. And when the cells in your multiwell plate die after compound treatment, it’s not enough to know that they died. You need to know how they died: apoptosis or necrosis? Or, have you really just reduced viability, rather than induced death? Is the cytotoxicity you see dose-dependent? If you look earlier during drug treatment of your cells, do you see markers of apoptosis? If you wait longer, do you observe necrosis? If you reduce the dosage of your test compound, is it still cytotoxic? Continue reading “Describing Life and Death in the Cell”

In Defense of Beautiful Weeds

The other evening my kids and I walked to the park. My four-year old daughter ran ahead through the dandelion-filled field, laughing with abandon.  She ran back to me and held out a treasured handful of bright yellow blossoms.

“Here Mommy! Aren’t they beautiful?”

Her seven-year old brother sniffed disdainfully. “They are just weeds.”

My daughter, the free spirit, turned and ran back through the field. Her reply was tossed carelessly over her shoulder. “No, they are beautiful weeds.” Continue reading “In Defense of Beautiful Weeds”

STATs and ChIPs- Learning A Lesson Or Two About Transcriptional Activation

During my childhood, my family and I spent many a vacation in the Swiss Alps.  From the mountain tops I used to look out into the horizon as far as the eye could see with peak upon peak stretching out into the distance.  If I was lucky, I would have a map that allowed me to identify each peak, perhaps even distinguish the highest from the lowest and thus really get a sense that I understood the underlying topography.  However, I quickly realized how little I actually knew about the vast, undulating Swiss countryside.  What I had initially observed as a homogenous ‘mat’ of peaks stretching out into the horizon was in fact a rippling of deep valleys that would make an afternoon hike anything but a walk in the breeze. 

 
Looking back on these experiences I am struck by how closely they reflect the landscape of modern science— a broad mat of detailed knowledge with its own peaks of specialization.  I am reminded of the words of writer Bill Bryson who described science as “tens of thousands of people that do tiny, tiny things that all accrete into a larger body of knowledge” (1).  Continue reading “STATs and ChIPs- Learning A Lesson Or Two About Transcriptional Activation”

H1N1 Influenza

swine_flu_headline

It’s hard not to panic in the light of recent pandemic fears and the frightening possibilities conjured up by the thought of a novel flu virus with the propensity for person-to-person spread (1-3). The specter of the 1918 pandemic has raised its ugly head, and we are left feeling intensely vulnerable to an invisible and ever-changing enemy. Have science and history left us more prepared to combat this virus than those who suffered during the devastating 1918 outbreak?

Continue reading “H1N1 Influenza”