Summer Friday Blog: This Week We Travel to Hawaii and Peshtigo, WI to Learn about Firestorms

Fire-whirlThis week’s video takes us to a forest fire on Mauna Kea, a dormant volcano on the island of Hawaii. One of the firefighters captured this amazing video of a fire whirl that erupted as the air temperature near the ground grew very hot. Fire whirls like this one are caused by extreme heat rising from the ground rather than a confluence of atmospheric events, but they can be be every bit as destructive as atmospheric tornadoes and cause a forest fire to continue to burn out of control.

There are written records of fire tornadoes including several that developed after lightning struck an oil storage facility near San Luis Obispo, CA, USA in 1926. In 2003, scientists confirmed true fire tornadoes in Australia associated with the Canberra fires. In this case the fire tornadoes produced damage consistent with the intensity of an F2 tornado. In The Great Pestigo Fire in 1871, the town of Peshtigo, WI, may well have been consumed by fire tornadoes. Dry weather conditions and slash and burn farming practices contributed to this devastating fire (as they did the more famous Chicago fire that occurred on the same day). Strong winds carried a forest fire into the mill town of Peshtigo, WI, and researchers theorize that cut timber and wooden structures of the town fueled such intense heat that a massive fire whirls formed, consuming the town. You can read some compelling stories about the Peshtigo fire here and here.

Understanding the conditions under which firestorms and fire tornadoes form hopefully will lead to a better understanding of how forest and brush fires spread and allow scientists and fire control experts to develop more effective methods of control.

Promega Art Showcases Explore Creativity, Science and the Unknown

A visitor studies a piece at the current Promega Art Showcase.
A visitor studies a piece at the current Promega Art Showcase.

Albert Einstein once wrote: “to raise new questions, new possibilities, to regard old problems from a new angle requires creative imagination and marks real advances in science.” The marriage of science and creativity, it seems, is indispensable for exploration and the discovery of new ideas.

As a life sciences company, Promega supports the work of scientists who are tasked with unraveling mysteries and who ask questions in an effort to get answers that improve the lives of others. Because creative thinking plays a key role in the scientific discovery process, Promega supports artistic exploration in many forms. As an organization, we appreciate that creativity reinforces the type of imagination that inspires scientific progress and innovation.

Since 1996, Promega Corporation has sponsored quarterly art showcases at the Promega BioPharmaceutical Technology Center on East Cheryl Parkway in Fitchburg, WI. This artistic initiative came about in an effort to explore the depths of creativity and science, and to demystify biotechnology and the work of Promega for our community. Promega Art Showcases, which occur four times per year and are open to the public, have featured the work of local, national and international artists, as well as the art of Promega employees. Continue reading “Promega Art Showcases Explore Creativity, Science and the Unknown”

Spring Break Staycation

A picnic and play in a local park can be part of your staycation
A picnic and play in a local park can be part of your staycation
Spring Fever! It seems everyone has it around here. Last week, people were the happiest I have seen in a while, and I’m certain the nicer weather had a lot to do with that. With school-age children, it seems that Spring Break is a hot topic of conversation, but an exotic vacation is not always possible for families. So, what can you do if you aren’t taking a Spring Break trip but still want to do something fun with the family? We’ve done staycations a couple times in the past. An overnight in a motel is like a vacation to my children, so that’s popular, but we are looking for new ideas. Here are a few that have been suggested:

  • Camping out! The weather isn’t quite there yet in Wisconsin, but getting out the sleeping bags and having flashlights in the family room is super fun. No electronics, so you get to spend some time together without movies, cell phones or video games.
  • Movie Marathon! We’ve picked a certain type of movie (robots, monsters, etc.), and made popcorn with sweet treats. Pajamas all day on the couch.
  • Scavenger Hunt! Who doesn’t love one? Take the time to create a really fun one that will take a while to get through. This will keep your family entertained for a couple hours if you do it right.
  • Spend the day like a tourist in your own town! There are so many places that get overlooked in our own communities because we are too busy living our lives to explore. I’ve never been to a local museum here! Do some things that people travel to your city to do and see.
  • Family Board Game Tournament! You will be surprised how much fun you can have playing board games. Mix it up so you have a variety. Prizes and snacks too!

What are your staycation ideas?

Biotechnology Ice Breakers: A Few Conversation Starters

quiz pictureThe biotechnology industry is one of the most dynamic out there – in fact, it never stands still! For non-scientists this can be intimidating. For scientists, it can be challenging to explain what we do in ways that non-scientists can understand and appreciate.

Scientists have made great strides in improving our ability to use molecular processes to our advantage, from discovering the basics of how to isolate and manipulate DNA to gaining an understanding of how genes direct the creation of proteins in cells.  It’s clear that there is a lot we can contribute to the scientific literacy of the general public.

In this spirit, we’ve designed a short quiz for both non-scientists (you may learn something new) and scientists (you may find it useful for engaging in conversations with your non-scientist friends and family members).  Spoiler alert: answers are provided. Continue reading “Biotechnology Ice Breakers: A Few Conversation Starters”

MicroRNAs as Circulating Biomarkers

12097693_lMicroRNAs (miRNAs) are short strands of RNA averaging between 19-24 nucleotides in length that were first discovered in C.elegans and subsequently shown to exist in species ranging from algae to humans (1). Speculated to be merely “junk” more than a decade ago, miRNAs have emerged as powerful regulators of a wide array of cellular processes because of their influence on gene expression at the posttrancriptional level. Dysregulation of these miRNAs is also associated with life-threatening conditions such as cancer and cardiovascular disease, which points to a potential use of miRNAs in diagnosis and treatment. Recently, it has been demonstrated that miRNAs are present in circulating blood plasma, protected from degradation by inclusion in lipid or lipoprotein complexes. This opens up the possibility to exploit miRNA as a useful diagnostic tool in clinical samples. Continue reading “MicroRNAs as Circulating Biomarkers”

General Considerations for Transfection

Many studies, from reporter assays to protein localization to BRET and FRET, require successful transfection first. Yet, transfection can be tricky and difficult. There are many considerations when planning transfection of your cells including reagent selection, stable or transient experiment, type of molecule and endpoint assay used. Here we discuss these considerations to help you plan a successful transfection scheme for your experimental system. Continue reading “General Considerations for Transfection”

How MicroRNAs Have a Big Effect on Genetic Regulation

miR-133 microRNA (green) and myogenin mRNA (red) in differentiating C2C12 cells. Image by Ryan Jeffs, courtesy of Wikimedia Commons.
miR-133 microRNA (green) and myogenin mRNA (red) in differentiating C2C12 cells. Image by Ryan Jeffs, courtesy of Wikimedia Commons.

Some of us scientists who have been around for a while still think about RNA molecules falling into three categories: messenger RNA (mRNA), ribosomal RNA (rRNA) and transfer RNA (tRNA). However, I have revised my outdated RNA classification scheme as scientists discover exciting new classes of RNAs that do some fairly amazing things. For example, in the early 1980s, Thomas Cech discovered ribozymes, RNAs that have catalytic functions (1), and in the early 1990s, researchers began to take interest in short noncoding RNAs that act as a genetic regulators, the first of which was discovered in C. elegans (2). RNA is no longer simply a biological middleman between DNA and protein. These ephemeral nucleic acid molecules play a much bigger role of cellular physiology and gene regulation than we had previously ascribed to RNA.

Continue reading “How MicroRNAs Have a Big Effect on Genetic Regulation”

Reflecting on the Future: Hands-On, Person-to-Person Educational Experiences

iStock_000053412884LargeThe start of a new year is always a good time for reflection.  For those of us at the BioPharmaceutical Technology Center Institute (BTC Institute), this means looking at the programs we offer and considering ones we might like to develop.

In this process, we find ourselves continuing to feel certain that the hands-on, lab-based opportunities we provide add something meaningful to the education of those we serve, from middle school students and their teachers to graduate students to scientists in academia and industry.  The value of learning concepts and techniques in a well-equipped setting, working with teachers and volunteers who are dedicated scientists, is significant.

In addition to gaining an understanding of the basics of molecular biology so key to biotechnology, these programs are also designed to support the development of critical thinking skills so necessary to scientific literacy.

We think this is also the case for our scientific symposia (Wisconsin Stem Cell Symposium; Wisconsin Human Proteomics Symposium) and our International Forum on Consciousness.  These events enable attendees to interact with speakers and other participants in person – in an environment designed to encourage the exchange of information, ideas and perspectives. Continue reading “Reflecting on the Future: Hands-On, Person-to-Person Educational Experiences”

Is Artificial Intelligence a Threat to Mankind?

Artificial intelligenceTechnology: We all use it, and some of us couldn’t go an entire day without it. In many ways, digital technology has improved our lives by increasing productivity and communication. Computer technology is everywhere: our homes, offices, phones and even cars. Technology has integrating into our lives so completely that most of us no longer stop to marvel at even the [seemingly] simplest capabilities such as the predictive software that our smart phones use to predict which word we are typing after we type in only the first few letters, especially if the software gets it wrong much of the time. However, digital technology has its dangers and inconveniences: cybercrime, hackers, stolen data, and computer crashes and failed Wi-Fi connections at the most inopportune times. In a recent BBC interview, one of modern science’s most brilliant minds highlighted another potential danger: artificial intelligence. Does artificial intelligence pose a threat to mankind?

Continue reading “Is Artificial Intelligence a Threat to Mankind?”

Dark Chocolate Benefits Improved by Fiber

Add pomegranate to your chocolate, says researcher Finley, to aid it's digestion, health benefits.
Add pomegranate to your chocolate, says researcher Finley, to aid it’s digestion and health benefits.

For chocolate lovers (and chocolate makers) it has been a great decade or so. Scientific research continues to prove what our brains have been saying for years; chocolate really IS good for us.

Research over the past decade or so has studied dark chocolate and its polyphenolic compounds, such as catechin and epicatechin, for their effects on inflammation, and cardiac and endothelial cell function. Today, from the American Chemical Society meeting in Dallas, TX, we learn new details about how dark chocolate brings its health benefits.

Before beneficial compounds in dark chocolate can reach the heart and other tissues in the body, digestive processes must occur to release the beneficial compounds from the chocolate.

Researcher John Finley and cohorts from Louisiana State University created a model digestive system by which to study what happens when cocoa combines with typical gut bacteria.

Their research showed that bacterial species in the colon ferment the fiber found in cocoa, which in turn aids in digestion of the larger polyphenols in cocoa, into smaller, more easily absorbed molecules. These smaller molecules, the catechins and epicatechins then enter the bloodstream and exert their anti-inflammatory effects.

Finley emphasized the role of dietary fiber, such as the fiber in the cocoa powders tested in this research, in the digestion process. He noted that prebiotics, carbohydrates in foods like raw garlic or cooked whole wheat flour, while not digested by humans, aid digestion and absorption of healthful food components, in this case polyphenols in dark chocolate.  Continue reading “Dark Chocolate Benefits Improved by Fiber”