Writing Scientific Papers: Is There More To This Story?

science & storytelling

The tactic of “telling a good story” is nothing new within the business of selling, marketing and even educating about science. The word itself, “storytelling,” achieved buzzword status a few years ago in the corporate world, so it’s no surprise that it now touches industry scientists.  But the importance of telling a good story within the realm of peer-reviewed scientific papers?  That is something new, and it may impact how scientists write up their results from this point forward.

In a provocative scientific study published in PLOS ONE in December 2016, researchers from the University of Washington showed that “Narrative Style Influences Citation Frequency in Climate Change Science.” Perhaps the results they report are unique to climate change science—an area of science especially susceptible to public perception. But then again, perhaps not. This paper may be worth considering no matter what field of science you call your own.

The authors—Ann Hillier, Ryan Kelly, and Terrie Klinger—used metrics to test their hypothesis that a more narrative style of writing in climate change research papers is more likely to be influential, and they used citation frequency as their measure of influence. A sample of 732 abstracts culled from the climate change literature and published between 2009 and 2010 was analyzed for specific writing parameters. The authors concluded that writing in a more narrative style increases the uptake and influence of articles in this field of science and perhaps in scientific literature across the board.

Continue reading “Writing Scientific Papers: Is There More To This Story?”

Top Science Books of 2016

While I planned to write about New Year’s resolutions for the first Promega Connections blog of 2017, I was sidetracked by some “best of 2016” lists—in particular, best science books. I realized though that these seemingly unrelated ideas overlapped at some level because every year I resolve to find time to read more books. What was once an easy and natural escape for me, like for so many others, reading for fun now requires a bit of effort and prioritization. With the continual distractions of Netflix, social media and online news stories, it’s a challenge to find time to read books the way I once did.

So, in honor of a new year’s resolution do more of what I like and less of what I don’t like, here is a list of what has been deemed the best science books of 2016. I culled through the lists of several of the most reputable science blogs and publications and looked for overlap among them. Between the Science Friday blog, New York Magazine’s blog, The Science of Us, Smithsonian Magazine, NPR, and the New York Times’ best of 2016 lists there are loads of suggestions to keep you reading until the start of the next decade. Below are eight recommendations that appeared on several “best of” lists. Continue reading “Top Science Books of 2016”

The Role of the NanoLuc® Reporter in Investigating Ligand-Receptor Interactions

Luminescent reporter assays are powerful research tools for a variety of applications. Last March we presented a webinar on this topic, Understanding Luminescent Reporter Assay Design, which proved to enlighten many who registered. The webinar addressed the importance of careful experimental design when using a luminescent reporter such as Promega’s Firefly or NanoLuc® Luciferase.

Reporters provide a highly sensitive, quantifiable metric for cellular events such as gene expression, protein function and signal transduction. Luminescent reporters have become even more valuable for live, real-time measurement of various processes in living cells. This is backed by the fact that a growing number of scientific publications reference the use of the NanoLuc® Luciferase reporter and demonstrate its effectiveness as a reporter assay. Continue reading “The Role of the NanoLuc® Reporter in Investigating Ligand-Receptor Interactions”

To Seq, or Not to Seq

Seq—shorthand for “sequence”— has become a more recognizable term thanks to a novel and provocative genomics initiative called the BabySeq Project. The project, officially launched in May 2015, was designed to explore the impact of whole-exome sequencing (WES) on newborn infants and their families. A randomized, controlled trial to sequence healthy and sick infants and then provide sequencing information, it is the first of its kind. Those infants randomized to receive WES undergo genetic sequencing of all protein-coding genes and analysis of about 1,700 genes implicated in childhood health, along with 18 years of follow up genetic counseling.29813751-nov-2-blog-post-nicole-600x470-web

The project is directed by Robert C. Green, geneticist and physician at Brigham and Women’s Hospital, Harvard Medical School and the Broad Institute, and Alan H. Beggs of Boston Children’s Hospital and Harvard Medical School. Funding, totaling $25 million, comes from the National Institute of Child Health and Development and the National Human Genome Research Institute. Continue reading “To Seq, or Not to Seq”

Of Elephant Research and Wildlife Crime – Molecular Tools that Matter

Here at Promega we receive some interesting requests…

Take the case of Virginia Riddle Pearson, elephant scientist. Three years ago we received an email from Pearson requesting a donation of GoTaq G2 Taq polymerase to take with her to Africa for her field work on elephant herpesvirus. Working out of her portable field lab (a tent) in South Africa and Botswana, she needed a polymerase she could count on to perform reliably after being transported for several days (on her lap) at room temperature. Through the joint effort of her regional sales representative in New Jersey/Pennsylvania (Pearson’s lab was based out of Princeton University at the time) and our Genomics product marketing team, she received the G2 Taq she needed to take to Africa. There she was able to conduct her experiments, leading to productive results and the opportunity to continue pursuing her work.

Continue reading “Of Elephant Research and Wildlife Crime – Molecular Tools that Matter”

The Cell Line Identity Crisis

29981164-Whistle

If you work with cell lines you may have paid attention to the dramatic headline published last month in the online journal STAT, Thousands of studies used the wrong cells, and journals are doing nothing.” In their column The Watchdogs (“Keeping an eye on misconduct, fraud, and scientific integrity”), Ivan Oransky and Adam Marcus call out the fact that scientists continue to publish research using cell lines that are contaminated or misidentified. Recent estimates have found that the percentage of misidentified cell lines used by scientists is as high as 20 to 36. The blame here is being placed on the peer reviewed journals for not blowing the whistle. The authors call for journals to put some “kind of disclaimer on the thousands of studies affected.”

This is not a new claim. The continuing problem of cell line misidentification, of lack of authentication, has been covered before in various channels. It’s easy to find news publicizing yet another retracted publication. In May 2015 the journal Nature required authors of all submitted manuscripts to confirm the identity of cell lines used in their studies and provide details about the source and testing of their cell lines.

Continue reading “The Cell Line Identity Crisis”

The Science of Fireworks

FireworksAnother Independence Day is in the books, and for many of us in the U.S. it included spending time with friends, family, food and the traditional holiday fireworks. Around the world, fireworks add to the enjoyment of many annual celebrations and events. Their colorful visual and audio display has the ability to thrill us, no matter what age we are. Despite growing older I never seem to tire of fireworks; I’ve also noticed that with each passing year the show seems to get more sophisticated. Whether it be a new color or shape or design of firework, pyrotechnic technology seems to improve at an impressive rate.

That got me thinking… how do fireworks actually “work”? Basic chemistry and physics are clearly at play, so in the spirit of a science-related blog I decided to look into this and share what I’ve learned. Continue reading “The Science of Fireworks”

A Day In the Life: Mikael Arnfelt, Promega Sales Manager, Sweden

*Today, June 6, is Swedish National Day – a fitting day to highlight this Promega employee.

Promega sales representatives worldwide find themselves on the road on a regular basis—it is, after all, part of the job description. Traveling many miles to visit customers, they’re fortunate to enjoy a steady change of scenery and a variety of daily tasks.

Mikael at a Finnish police lab where he was servicing a Maxwell instrument.
Mikael at a Finnish police lab where he was servicing a Maxwell instrument.

For Mikael Arnfelt, Sales Manager of Promega’s Sweden branch, travel obligations are sometimes taken to a higher level. That’s why we wanted to share his adventures for our “Day In the Life” series; though as Mikael is quick to point out, there’s really no such thing as a “typical day,” at least not in his life!

Mikael’s experiences begin to make sense once you learn more about his position with Promega. “We are a small branch, so we each need to take on multiple roles,” he explains. “In the beginning I was the only sales rep for Sweden, so until last year I took care of southern Sweden and all of Finland/Estonia, together with our distributors there.” He and his few colleagues are also responsible for many different product groups—Mikael’s include Detection Instruments, Cellular Analysis, and Applied Markets. “I am also the back-up for order taking,” he says. “I currently cover this seven days a month, and during vacation periods, so my colleague can work on various administrative tasks, and even take some vacation himself.” Continue reading “A Day In the Life: Mikael Arnfelt, Promega Sales Manager, Sweden”

The Making of a Promega Product: Teamwork = Success for the Maxwell RSC® ccfDNA Plasma Kit

Ever think about the kinds of challenges R&D scientists run up against in the course of developing a new product? The development of the Maxwell® RSC ccfDNA (circulating cell-free DNA) Plasma Kit is a particularly interesting example. Its path to commercialization was characterized by a number of unexpected technical hurdles, yet each was overcome through creative troubleshooting and aided by valuable collaborations across departments. All had a hand in finally launching the kit last August.

26062525-ccfDNA_Mar25-blog-DNAThe product’s launch was an exciting milestone for Promega as research interest in the role of ccfDNA as biomarkers in human disease continues to grow. Elevated levels of ccfDNA have now been reported in patients with cancer, inflammatory disease, infections and cardiovascular disease. In pregnant women, up to 10% of ccfDNA can be attributed to the fetus, so critical fetal DNA analysis can now be conducted through maternal blood samples. There are many advantages in the ability to isolate and analyze ccfDNA, so the development of a kit with high throughput capability was a priority for the Nucleic Acid Purification R&D team. Continue reading “The Making of a Promega Product: Teamwork = Success for the Maxwell RSC® ccfDNA Plasma Kit”

A Walk Around the Promega Campus: Honoring Some of the Greats of Science

Leonardo da Vinci
Leonardo da Vinci

The Promega campus in Madison, Wisconsin has been fortunate to welcome several new buildings in recent years. While some of the older buildings are fondly known by their acronyms – BTC for BioPharmaceutical Technology Center and RDC for Research & Development Center – other names are more descriptive. Notice a particular theme to these buildings’ names: Faraday, Franklin, da Vinci, Feynman, Kepler? Legendary scientists all, with visionary minds, they serve to inspire and remind us of the possibilities that Promega employees can achieve.

Given the impressive pool of Nobel Prize recipients, inventors and innovators to consider as namesakes of Promega buildings, why were these particular individuals chosen? And, who exactly were they? Continue reading “A Walk Around the Promega Campus: Honoring Some of the Greats of Science”